Today’s Solutions: May 27, 2022

Our bodies have to regulate many processes daily: temperature, hydration, mineral balance, sugar levels, and many more. When these regulating processes get out of whack, this can lead to diseases and other serious health complications. This is exactly what happens in diabetes, where specialized cells in our bodies lose their ability to sense blood sugar levels and how to adjust them.

Drugs, such as SGLT2 inhibitors, are prescribed to treat diabetes, helping the body decrease the amount of glucose in the blood. A research team from the University of Missouri School of Medicine may have just found another way this medication can be utilized to protect against one of the world’s biggest killers: heart disease.

“Cardiovascular disease is the main cause of death in older adults in the U.S.,” said Camila Manrique-Acevedo, MD, associate professor of medicine. “Weight loss, physical activity, antihypertensive therapy, and lipid-lowering drugs have shown variable effectiveness at improving blood vessel function and reducing arterial stiffness. But additional approaches are needed to improve vascular health in older adults.”

Blood vessels and aging

The team set out to evaluate blood vessel function and stiffness in 18 healthy human patients, ranging from 18 to 61. They found that the older patients had impaired endothelial function and increased aortic stiffness when compared to the younger patients.

“Our findings in young and older adults confirm previous clinical data demonstrating the impact of aging on blood vessel function and arterial stiffness,” Manrique-Acevedo said. “Importantly, we were able to replicate this data in a rodent model.”

How do SGLT2 inhibitors improve vascular health? 

To test the potential impact of SGLT2 inhibitors, the team looked at the difference in vascular aging in mice whose diet was enriched in the drug and one that was not. After six weeks, the different groups were analyzed and it was found the mice with the drug added to their diet experienced improved blood vessel function, reduced arterial stiffness, and other vascular benefits.

As this is the first study to examine the role of SGLT2 inhibition in vascular aging, the group wants to conduct further clinical investigations to fully determine its impact. However, this study is a great start in finding an effective and needed treatment against heart disease.

Source study: GeroScienceSGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice

Solutions News Source Print this article
More of Today's Solutions

US injects $3.5 billion into carbon removal technologies

The US has ambitious goals to reach and maintain a net-zero economy by 2050. To get the nation closer to this objective, the US Department of Energy (DOE) is accelerating its Carbon Negative Shot initiative ... Read More

Pennsylvania schools doubled their solar power in the last two years

Renewable energy production is taking off in the Keystone State. A new report from the nonprofit Generation180 reveals that Pennsylvania schools doubled their solar power capacity over the last two years of the Pandemic. This ... Read More

Recycled old tires could make roads last twice as long

Prolonged sun exposure is one of the main contributors to asphalt cracking. That’s because the heat from the sun dries up the road’s moisture content, making it brittle and prone to wear. A team of ... Read More

Germany slashes public transportation costs to reduce fossil fuel dependence

In the energy standoff between Europe and Russia, Germany has taken many measures to accelerate the phasing out of oil and gas. It has resolved to make energy cheaper for homes and businesses. It has ... Read More

Want to keep sharks and beachgoers safe? There’s an app for that

Sharks, as top predators, are a keystone species. This means the balance of whole marine ecosystems relies heavily on sharks' well-being. Protecting and conserving sharks is of the utmost importance, especially since they already face ... Read More

New gel film pulls drinking water from the air in even the driest places

Getting water to drought-stricken areas is an increasing concern for scientists. In the future, desalination systems will become simpler and more accessible to get water to those who need it, but another solution could be ... Read More


Emissaries, Log in to hide this reminder

You have read 3 aricles on The Optimist Daily. Support reader-funded independent journalism. Help us make a difference in the world, shifting consciousness towards a solution focused mindset.

For just $5 per month Emissaries have access to unlimited solutions and a community of like minded positive thinkers.